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Mitochondrial function
The cellular power source for every organ system. When the mitochondria dim, fatigue, brain fog, insulin resistance, and accelerated aging follow.
FOUNDER & CHIEF MEDICAL OFFICER
Dr. Pranav Kumar Sharma, MD.
MD · FACC · FCCP · FASN · D-ABOM
A board-certified physician with multidisciplinary training in internal medicine, cardiovascular medicine, nephrology, critical care, and metabolic and obesity medicine. Clinical experience across the United States and internationally. The medical conscience behind every Bionomy protocol.
“The work of modern medicine is no longer to wait for disease. It is to read the body early, understand its signals at the cellular and mitochondrial level, and intervene with evidence before the failure ever arrives.”
Dr. Pranav K. Sharma, MD
A LONG-FORM BIOGRAPHY
The physician behind Bionomy.
Dr. Pranav Kumar Sharma is a board-certified physician with multidisciplinary training in internal medicine, cardiovascular medicine, nephrology, critical care, and metabolic and obesity medicine, with clinical experience in both the United States and internationally. His diverse background provides a comprehensive and integrative framework for managing complex medical conditions, with a particular focus on metabolic health, obesity-related disease, cardiovascular risk reduction, and longevity-focused care.
Clinical and academic interests
Dr. Sharma’s clinical and academic interests center on metabolic optimization, obesity medicine, preventive cardiometabolic health, and evidence-based longevity science. He is actively involved in the evolving fields of anti-aging and regenerative medicine, with a strong emphasis on translating emerging scientific advances into safe, practical, and patient-centered clinical strategies.
A holistic, mitochondria-first framework
His work focuses on developing a holistic approach to health that integrates body and mind at the metabolic and mitochondrial levels. His areas of interest include mitochondrial function, oxidative stress reduction, antioxidants, coenzyme Q10 biology, cellular repair and regeneration, inflammation modulation, metabolic flexibility, and healthy aging pathways including telomere biology and cellular longevity research. He is particularly interested in evidence-based interventions that support long-term vitality, functional health, and disease prevention.
Education and mentorship
In addition to his clinical work, Dr. Sharma is actively engaged in medical education and has extensive experience teaching medical students, residents, and fellows. He is committed to simplifying complex physiological and metabolic concepts into practical, high-yield learning that supports both trainee development and excellence in patient care.
A career of merit-based examination
Dr. Sharma has successfully completed multiple merit-based examinations and board certifications across different healthcare systems, reflecting a strong commitment to academic rigor, innovation, and lifelong learning. As a longevity and fitness physician, he aims to promote scientifically grounded, clinically relevant research while upholding high standards of evidence, ethics, and integrity in the advancing fields of metabolic medicine, regenerative therapies, and longevity science.
CLINICAL EDUCATION
“If a resident cannot draw the Krebs cycle on a whiteboard, they cannot reason about a patient who is failing on a GLP-1. The biochemistry is the medicine.”
RESEARCH AND CLINICAL INTERESTS
Where his curiosity lives.
A working list of the questions that occupy his clinical reading and his bedside reasoning.
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Coenzyme Q10 biology
An endogenous lipid-soluble antioxidant central to mitochondrial ATP production. Levels decline with age and with statin use.
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Oxidative stress reduction
The imbalance between free radicals and antioxidant defense. Implicated in cardiometabolic disease, neurodegeneration, and skin aging.
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Cellular repair and regeneration
Autophagy, mitophagy, and regenerative pathways that decide whether a cell renews itself or becomes senescent baggage.
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Inflammation modulation
Chronic low-grade inflammation as the common soil of cardiovascular disease, insulin resistance, and most of what eventually kills men.
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Metabolic flexibility
The body’s ability to switch cleanly between burning carbohydrate and burning fat. The marker that separates healthy aging from metabolic decline.
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Telomere biology
The protective caps at the ends of chromosomes. Their shortening is the closest proxy science currently has to a cellular clock.
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Cellular longevity research
Senolytics, NAD+ precursors, rapamycin analogs, and metformin. The interventions where the evidence is moving fastest.
A PHILOSOPHY OF CARE
Body and mind, integrated at the cellular level.
The mitochondrial lens
Almost every chronic condition that arrives in a midlife man, low energy, low testosterone, visceral fat, insulin resistance, depressed mood, share one shared substrate. The mitochondria are tired. Treat the substrate and the symptoms reorganize.
Evidence over fashion
The longevity space is loud. Bionomy prescribes only interventions with reproducible human data, transparent dosing, and a published safety profile. Compounded medication is not a wellness aesthetic, it is a regulated therapy.
Long horizons
Care plans are written for decades, not for the next refill. A protocol that improves a lab today but accelerates kidney disease at fifty-five is not a protocol Bionomy will ship.
Teaching as medicine
The most durable contribution a physician makes is to the next generation of physicians. Dr. Sharma teaches because the bedside is downstream of the classroom.
TRAINING PATHWAY
A twenty-year arc through four health systems.
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2025
American Board of Obesity Medicine, D-ABOM
The fourth American board. Governs GLP-1 prescribing for non-diabetic adults. Held by fewer than 8,000 physicians in the United States.
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2023
American Board of Critical Care Medicine
Subspecialty for physicians managing the sickest patients in the hospital. Mechanical ventilation, ECMO, advanced hemodynamics.
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2022, 2023
Critical Care Medicine Fellowship
Montefiore Medical Center at the Albert Einstein College of Medicine, New York.
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2022
American Board of Nephrology
Specialty board for kidney and metabolic physiology. Foundational for safe TRT, GLP-1, Metformin, and NAD+ titration.
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2020, 2022
Nephrology Fellowship
Robert Wood Johnson School of Medicine at Rutgers University, New Jersey.
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2020
American Board of Internal Medicine, ABIM
The foundational board for adult medicine in the United States.
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2017, 2020
Internal Medicine Residency
Bronx Care Health System at the Icahn School of Medicine at Mount Sinai, New York.
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2014, 2017
DNB Cardiovascular Disease Fellowship
Apollo Hospitals, New Delhi. International cardiovascular subspecialty training.
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2000, 2006
MBBS, Stanley Medical College
University of Madras, Chennai. The beginning of a long road.
CURRENT APPOINTMENTS
Where he practices, teaches, and writes.
CLINICAL LEADERSHIP
Medical Director, Intensive Care Services
Lake Cumberland Regional Hospital, Somerset, Kentucky
HOSPITAL GOVERNANCE
Co-Chair, Patient Safety and Clinical Quality Committee
Lake Cumberland Regional Hospital
FOUNDING ROLE
Founder & Chief Medical Officer
Bionomy Health, Los Angeles, California
ACADEMIC FACULTY
Clinical Professor of Critical Care Medicine
University of Pikeville, Kentucky College of Osteopathic Medicine
ADJUNCT FACULTY
Clinical Preceptor, Adjunct Faculty of Medicine
Lincoln Memorial University, DeBusk College of Osteopathic Medicine
TEACHING FACULTY
Instructor, Critical Care Echocardiography
National Board of Echocardiography certified instructor
BOARDS, FELLOWSHIPS & HONORS
The credentials, in full.
Every certification below is verifiable. We list them not as ornament, but because the standard of care a physician brings is the standard of care your protocol receives.
AMERICAN BOARD CERTIFICATIONS
- American Board of Obesity Medicine (D-ABOM)2025
- American Board of Internal Medicine, Critical Care Medicine2023
- American National Board of Echocardiography (NBE), Critical Care Echocardiography2023
- American Board of Internal Medicine, Nephrology2022
- American Board of Internal Medicine (ABIM)2020
- ECFMG Certification2016
FELLOWSHIPS & FACULTY HONORS
- FACCFellow, American College of Cardiology
- FCCPFellow, American College of Chest Physicians
- FASNFellow, American Society of Nephrology
- Triple American board-certified physicianInternal Medicine, Nephrology, Critical Care
- International & National SpeakerCritical Care Conferences and CMEs
- Moderator, Research Snapshot Theater2026 Society of Critical Care Congress (SCCM)
- Reviewer, American Journal of Case ReportsEditorial peer review
- Reviewer, Society of Critical Care MedicineSCCM Journal & Critical Care Congress
- Reviewer, American Society of NephrologyKidney Week conference & ASN Journals
- Recognized for in-flight CPR rescueInternational airline commendation, SCCM session proposal
ACTIVE MEDICAL LICENSURE
- State of KentuckyActive medical license
- State of New YorkActive medical license
ASSOCIATIONS
- American College of CardiologyFellow
- American College of Chest PhysiciansFellow
- American Society of NephrologyFellow
- Society of Critical Care MedicineMember, Reviewer
- American Board of Obesity MedicineDiplomate
PEER-REVIEWED PUBLICATIONS
Sixteen papers across cardiology, nephrology, and critical care.
Selected publications across leading American journals. Dr. Sharma’s clinical writing centers on cardiometabolic risk, acute care nephrology, and the science that informs every protocol at Bionomy.
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Sharma PK, Tripathi D, Kaushal A, Chaudhary SM, Choudhary N. Optimizing Multimodal Analgesia in Critical Care and Surgical Settings: Applications and Considerations.
SN Comprehensive Clinical Medicine, 2025; 7:229.
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Bhavsar T, Mundhra S, Kamboj R, Kaushal A, Kamboj M, Uthayakumar K, Singh A, Arora S, Chaudhary SM, Tripathi D, Sharma PK, Rai M. Comparative Efficacy of Cardiovascular Risk Prediction Tools: A Network Meta-analysis of Traditional, Radiological, and AI-Based Approaches.
SN Comprehensive Clinical Medicine, 2025; 7(1):1-10.
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Sharma P, Bhagat A, Aboyme A, Ibrahim F. Cardiac Tamponade and Acute Pulmonary Edema due to Lupus Myopericarditis and Lupus Nephritis Requiring Urgent Hemodialysis: A Rare Malignant Presentation of Lupus Flare-Up.
Journal of the American College of Cardiology, 2022 Mar; 79(9_Supplement):2573.
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Sharma P, Lebowitz J. Patient with Refractory Acquired Thrombotic Thrombocytopenic Purpura Treated with a Novel Agent Caplacizumab.
Journal of the American Society of Nephrology, 2021 Oct; 32:141.
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Sharma PK, Khalil S, Jonathan L. Nephrotic Range Proteinuria due to ANCA Associated Vasculitis in a Diffuse Systemic Sclerosis Patient: A Rare Presentation.
Journal of the American Society of Nephrology, 2021 Oct; 32:470.
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Sharma PK, Aboyme A, Ibrahim F, Tripathi N. The Dilemma of Undiagnosed Thyroid Disease in a Pregnant Woman.
Journal of the American College of Cardiology, 2021 May; 77(18):2263.
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Portugal F, Sharma P, Puri S, Bongu A. Transplant Renal Artery Stenosis: An Important Cause of Early Renal Failure.
American Journal of Kidney Diseases, 2021 Apr; 77(4):636.
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Saad M, Gurjar H, Rodriguez M, Sharma PK, Vittorio T. The Role of Cardioselective versus Non-Cardioselective Beta-Adrenergic Blockade in the Acute Phase of Takotsubo Cardiomyopathy.
Journal of Cardiac Failure, 2019 Aug; 25(8S):S28.
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Omar AM, Ronderos D, Caraballo J, Kim, Kachatoorian Y, Sharma PK, Abdel-Rahman MA. Combined Atrioventricular Longitudinal Strain Rate during Isovolumic Contraction Predicts Pulmonary Capillary Wedge Pressure in Patients with Systolic Dysfunction.
American Journal of Cardiovascular Disease, 2021 Jul. PMID: 34548952. PMCID: PMC8449199.
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Patnaik P, Sharma PK, Khalil S, Lebowitz J. Atraumatic Splenic Rupture in a Patient on Apixaban and Clopidogrel.
Journal of the American Society of Nephrology, 2021 Jun; 32:799.
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Sharma PK, Khalil S, Anwar MA, Portugal F, Greenberg P, Formanowski B. A Retrospective Analysis of Fluid Balance in Patients with Acute Kidney Injury and Respiratory Failure due to COVID-19.
2021 Jul.
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Sharma PK, Puri S. Transplant Renal Artery Stenosis as a Potential Cause of Early Allograft Failure.
Cureus, 2021 Feb 19.
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Sharma PK, Tripathi N. A Clinico-Epidemiological Profile of Acute Viral Hepatitis in Northern India.
International Journal of Medicine Research, 2016 Mar; 1:33-36.
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Tripathi N, Soni JP, Sharma PK, Verma M. Role of Haemogram Parameters and RBC Indices in Screening and Diagnosis of Beta-Thalassemia Trait in Microcytic, Hypochromic Indian Children.
International Journal of Hematological Disorders, 2015 Oct; 2(2):43-46.
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Sachdeva S, Amin SS, Khan Z, Sharma PK, Bansal S. Childhood Leprosy: Lest We Forget.
Tropical Doctor, 2011 May; 41(3):163-165. PMID: 21586510.
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Sachdeva S, Amin SS, Khan Z, Alam S, Sharma PK. Childhood Leprosy: A Retrospective Study.
Journal of Public Health and Epidemiology, 2010 Dec; 2(9):267-271.
WRITING FROM THE FOUNDER
Letters from the bedside, the bench, and the boardroom.
Five new essays from Dr. Sharma on the questions that shape Bionomy’s clinical thinking.
MITOCHONDRIAL MEDICINE
The mitochondrion and the midlife man.
Why the cellular power source is the single most important organ to understand after forty.
COENZYME Q10
CoQ10: what the evidence actually says.
The endogenous antioxidant every cardiologist watches and the lay public still misunderstands.
METABOLIC HEALTH
Metabolic flexibility, the real longevity marker.
Not blood pressure, not LDL. The marker that separates a healthy fifty from a tired forty.
OXIDATIVE STRESS
Oxidative stress and cardiometabolic risk.
The quiet driver underneath the loud diagnoses, and what a thoughtful physician does about it.
TELOMERE BIOLOGY
Telomeres and the clock inside your cells.
What telomere length tells us, what it does not, and where the evidence is actually moving.
MORE FROM THE LIBRARY
The full Bionomy editorial library.
TRT, GLP-1, peptides, sexual health, and hair, all reviewed by an American board-certified physician.
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Every Bionomy protocol is reviewed by Dr. Sharma or a Bionomy physician trained under his standard of care. Free intake. No card. Reviewed in 24 hours.
Begin intake, freeCompounded medications are not FDA-approved. They are prepared by state-licensed pharmacies for individual patients based on a prescription from a licensed physician.